Last updated on: November 30, 2025
Xeomin injection is a purified botulinum toxin type A injection used for both aesthetic and medical purposes. It helps reduce facial wrinkles and treats conditions caused by muscle stiffness, such as cervical dystonia and blepharospasm.
By blocking nerve signals, Xeomin relaxes muscles, making it effective for cosmetic treatments like smoothing forehead and eye wrinkles, as well as medical conditions involving muscle spasms. Unlike Botox and Dysport, it does not contain accessory proteins, which may lower the risk of antibody resistance.
This article provides a detailed overview of Xeomin, including its working mechanism, uses, duration of effects, possible side effects, cost, comparison with other botulinum toxin products, and where to obtain it.
Table of Contents
How Does Xeomin Work?
Xeomin works by stopping certain nerve signals that tell muscles to contract. When muscles stay relaxed, wrinkles on the skin become less visible, and conditions like muscle spasms or stiffness improve. After getting a Xeomin injection, it usually takes 3 to 7 days to see the full effect. The results last 3 to 6 months, depending on the area treated and the person’s body. Once the effects wear off, another treatment may be needed to maintain the results.
2. Uses of Xeomin Injections
Xeomin injections are used for both cosmetic and medical purposes.
1. Cosmetic Uses
Xeomin is widely used in dermatology and aesthetic treatments to reduce signs of aging by relaxing facial muscles. Common cosmetic applications include:
| Treatment Area | Effect of Xeomin |
|---|---|
| Forehead Wrinkles | Smooths horizontal lines on the forehead. |
| Frown Lines (Glabellar Lines) | Reduces vertical lines between the eyebrows. |
| Crow’s Feet | Minimizes fine lines around the eyes. |
| Lip Lines & Chin Dimples | Softens lines around the mouth and chin for a smoother appearance. |
2. Medical Uses
Apart from beauty treatments, Xeomin is also used to treat certain medical conditions related to muscle stiffness and overactivity, such as:
| Medical Condition | Effect of Xeomin |
|---|---|
| Cervical Dystonia | Relieves neck muscle spasms that cause pain and abnormal head positions. |
| Blepharospasm | Treats involuntary eyelid twitching and spasms. |
| Spasticity | Helps reduce muscle stiffness in conditions like cerebral palsy and post-stroke muscle tightness. |
| Hyperhidrosis (Excessive Sweating) | Controls excessive sweating by blocking nerve signals to sweat glands (off-label use). |
| Sialorrhea (Excessive Salivation) | Reduces drooling in patients with neurological disorders like Parkinson’s disease. |
How Many Units of Xeomin Are Needed?
The number of Xeomin units required varies based on the treatment area and the condition being treated. Below is a general guideline:
| Treatment Area/Condition | Approximate Units Needed |
|---|---|
| Forehead Wrinkles | 10 – 20 units |
| Frown Lines (Glabellar Lines) | 20 – 30 units |
| Crow’s Feet | 12 – 24 units (6 – 12 per side) |
| Lip Lines & Chin Dimples | 4 – 10 units |
| Cervical Dystonia | 50 – 200 units (varies by severity) |
| Blepharospasm | 25 – 50 units (divided between both eyes) |
| Spasticity | 100 – 400 units (depends on muscle size) |
| Hyperhidrosis (Excessive Sweating) | 50 – 100 units per area (e.g., underarms) |
| Sialorrhea (Excessive Salivation) | 30 – 100 units (divided between salivary glands) |
3. Xeomin Injection Procedure
How Xeomin is Administered
Xeomin injections are given by a qualified healthcare professional, typically a dermatologist, plastic surgeon, or neurologist, depending on the treatment. The procedure involves the following steps:
Post-Treatment Care – Patients are advised to avoid rubbing the area, lying down, or engaging in strenuous activities for a few hours after the injection.
Consultation – The doctor assesses the patient’s condition and determines the appropriate dosage.
Preparation – The treatment area is cleaned, and a numbing agent may be applied for comfort.
Injection – Xeomin is injected directly into the targeted muscles using a fine needle. The procedure is quick, usually taking 10 to 20 minutes.
Reconstitution & Storage
Storage: Before reconstitution, Xeomin can be stored at room temperature (up to 25°C/77°F). After dilution, it should be used within 24 hours and stored in a refrigerator at 2°C to 8°C (36°F to 46°F) to maintain effectiveness.
Reconstitution: Xeomin is supplied as a dry powder and must be diluted with sterile saline before use. The concentration depends on the treatment needs, typically 1.25 to 2.5 units per 0.1 mL.
4. How Long Does Xeomin Last?
The effects of Xeomin are temporary and typically last between 3 to 6 months, depending on the treatment area, dosage, and individual response. For cosmetic treatments like reducing forehead wrinkles, frown lines, and crow’s feet, results usually last 3 to 4 months. However, for medical conditions such as cervical dystonia, blepharospasm, spasticity, and excessive sweating (hyperhidrosis), the effects may last 4 to 6 months before requiring another treatment.
Several factors can influence how long Xeomin lasts. People with a faster metabolism may notice that the effects wear off more quickly, while those with a slower metabolism might experience longer-lasting results. Additionally, areas with frequent muscle movement, such as around the eyes and mouth, tend to break down the toxin faster than less active areas. The amount of Xeomin used also plays a role—higher doses can sometimes prolong the effects, but only when administered safely by a trained professional.
The technique of the injector is another important factor. A skilled healthcare provider ensures that the injection is placed correctly, helping Xeomin work effectively for the longest possible time. Over time, regular Xeomin treatments may lead to longer-lasting effects, as the targeted muscles gradually become conditioned to staying relaxed.
To maintain results, patients typically need follow-up injections every 3 to 6 months, depending on their response to the treatment. Consulting with a qualified doctor can help determine the ideal schedule for maintaining the desired effects.
5. Xeomin vs. Other Neurotoxins
Xeomin is one of several botulinum toxin type A injections available for both cosmetic and medical use. While it works similarly to Botox, Dysport, Jeuveau, and Daxxify, there are key differences in their composition, effectiveness, and longevity. Choosing the right neurotoxin depends on the patient’s needs, treatment goals, and how their body responds to the injection.
Xeomin vs. Botox vs. Dysport
Xeomin, Botox, and Dysport are all FDA-approved botulinum toxin injections used to relax muscles and reduce wrinkles. However, Xeomin differs from Botox and Dysport because it does not contain accessory proteins, making it a “naked” or purified form of botulinum toxin. This can help reduce the risk of the body developing resistance to treatment over time. Botox, on the other hand, contains additional proteins that may make it more stable for some patients but could also increase the chances of antibody resistance. Dysport has a different formulation that spreads more easily, making it a preferred choice for treating larger areas like the forehead.
In terms of results and longevity, Botox and Xeomin typically last 3 to 6 months, while Dysport may take effect slightly faster but can wear off sooner in some individuals. The choice between these options depends on how the patient responds to each formulation and their specific treatment needs.
Xeomin vs. Jeuveau & Daxxify
Jeuveau, sometimes called “Newtox,” is another botulinum toxin injection similar to Botox and Xeomin. It is primarily marketed for cosmetic use and is considered effective for reducing wrinkles. However, unlike Xeomin, Jeuveau contains additional proteins, which means it may carry a slight risk of the body developing resistance over time.
Daxxify is a newer neurotoxin that stands out because it is designed to last longer than Botox, Xeomin, and Dysport. While most botulinum toxin injections last 3 to 6 months, Daxxify has been shown to provide results for 6 to 9 months in some patients. However, because it is relatively new, long-term comparisons with Xeomin and other neurotoxins are still being studied.
Xeomin vs. Botox: What’s the Difference?
The primary difference between Xeomin and Botox is their composition. Xeomin is a purified form of botulinum toxin type A, meaning it does not contain any extra proteins. This can be beneficial for patients who have developed resistance to Botox over time. Botox, on the other hand, includes additional stabilizing proteins, which may help it work effectively in certain cases but could also increase the risk of antibody resistance.
Another key difference is storage and preparation. Xeomin can be stored at room temperature before reconstitution, while Botox must be kept refrigerated. This makes Xeomin more convenient for doctors and clinics. Additionally, some patients report that Xeomin provides a more natural look, while Botox may have a slightly stronger effect initially.
Ultimately, both Xeomin and Botox are highly effective, and the choice between them depends on individual response, treatment goals, and doctor recommendations.
6. Cost of Xeomin Injections
| Factor | Details |
|---|---|
| Cost per Unit | $8 – $15 per unit |
| Cosmetic Treatment Cost | $200 – $600 per session |
| Medical Treatment Cost | $500 – $1,500+ per session |
| Treatment Area & Units | Larger areas require more units, increasing cost |
| Provider’s Expertise | Specialists may charge higher fees |
| Clinic Location | Prices are higher in large cities |
| Medical vs. Cosmetic Use | Insurance may cover medical use, but not cosmetic |
| Promotions & Packages | Some clinics offer discounts for multiple sessions |
This table provides a clear cost breakdown for Xeomin injections based on different factors.
7. Side Effects & Risks of Xeomin
1. Common Side Effects (Mild & Temporary)
These are usually mild and go away on their own:
- Headache
- Pain, redness, or swelling at the injection site
- Dry eyes
- Nausea
- Dizziness
- Eyelid drooping (Ptosis or Eyelid Ptosis)
2. Less Common but Possible Side Effects
These side effects are less frequent but can occur in some patients:
- Dysphagia (difficulty swallowing)
- Muscle weakness
- Shortness of breath (Dyspnea)
- Dry mouth (Xerostomia)
- Joint pain (Arthralgia)
- Speech problems
- Blurred vision
- Fever
- Neck pain
3. Rare but Serious Side Effects
These side effects are rare but require immediate medical attention if they occur:
- Seizures
- Vision impairment
- Itching (possible allergic reaction)
- Urinary incontinence (loss of bladder control)
- Diarrhea
- Respiratory tract infection
- Bronchitis
- Sneezing
Precautions to Reduce the Risk of Side Effects
✔ Always get treated by a certified and experienced doctor.
✔ Avoid lying down or massaging the treated area for a few hours after the injection.
✔ Inform your doctor about any existing medical conditions or medications before treatment.
✔ Seek immediate medical help if you experience severe or long-lasting side effects.
Although Xeomin is generally safe, some individuals may experience side effects. If you notice any unusual symptoms, it is important to consult a doctor immediately.
8. Where to Get Xeomin Injections?
Xeomin injections should only be given by trained doctors or medical professionals to ensure safety and good results. There are different places where you can get Xeomin, depending on whether you need it for beauty treatments or medical conditions.
For cosmetic treatments, you can visit dermatology clinics, plastic surgery centers, or medical spas. Dermatologists and plastic surgeons are experts in reducing wrinkles and improving skin appearance. MedSpas also offer Xeomin, but you should make sure that a licensed doctor or nurse is supervising the treatment to avoid risks.
For medical conditions like neck muscle spasms (cervical dystonia), eyelid twitching (blepharospasm), or excessive drooling (sialorrhea), Xeomin is usually given at neurology clinics, pain management centers, or hospitals. These places have specialists who know the correct dose and injection points for medical treatments. In some cases, insurance may help cover the cost if Xeomin is used for a medical reason.
Some doctors offer at-home injection services, but it is very important to check if the provider is certified and using real Xeomin. When choosing a place for Xeomin, always check the doctor’s experience, read patient reviews, and make sure the clinic follows strict hygiene rules. This will help you get safe and effective treatment.
10.(FAQs)
Who Makes Xeomin injection?
Xeomin is manufactured by Merz Pharmaceuticals, a global leader in medical aesthetics.
Conclusion
Xeomin injections are a safe and effective alternative to Botox for reducing wrinkles and treating medical conditions. Whether you are considering it for cosmetic or medical reasons, consult with a professional for the best results.